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Scientists Are Developing ‘Injectable Bandage’ That Can Heal The Internal Injuries.
A team of the scientists, including one of Indian-origin, have developed an ‘injectable bandage’ that is a therapeutic gel which can heal potentially fatal internal injuries.
A penetrating injury from the shrapnel is a severe obstacle of overcoming the battlefield wounds that ultimately lead to death.
Given the high mortality rates due to a haemorrhaging, there is an unmet need to quickly self-administer materials that to prevent fatality due to an excessive blood loss.
With a gelling agent commonly using in preparing pastries, researchers from the Texas A&M University in the US have successfully fabricated an injectable bandage to stop bleeding and promote the wound healing.
The Researchers used the kappa-carrageenan and nano silicate to form injectable hydrogels to promoting hemostasis the process to stop bleeding and facilitating wound healing that is a controlled release of the therapeutics.
“Injectable hydrogels are promising the materials for achieving hemostasis in case of internal injuries and bleeding, as these biomaterials can introducing into a wound site using minimally invasive approaches.
“An ideal injectable bandage should solidify after injection in the wound area and promote a natural clotting cascade. Also, the injectable bandage should initiate the wound healing response after achieving the hemostasis,” says Gaharwar.
The study, publishing in the journal Acta Biomaterialia, uses a conventional thickening agent which is known as kappa-carrageenan, obtaining from seaweed, to design injectable hydrogels.
Hydrogels are a 3D water-swollen polymer network, similar to the Jell-O, simulating the structure of the human tissues.
When kappa-carrageenan is mixing up with clay-based nanoparticles, injectable gelatine is obtaining. The charged characteristics of clay-based nanoparticles are providing a hemostatic ability to the hydrogels.
Specifically, plasma protein and platelets from blood adsorbing in the gel surface to trigger blood clotting cascading.
We found that these injectable bandages can show a prolonging release of the therapeutics that can use to heal the wound,” says Giriraj Lokhande, a graduate student in Gaharwar’s lab.
“The negative surface charge of nanoparticles is enabled electrostatic interactions with the therapeutics thus resulting in the slow release of therapeutics,” says Lokhande.
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